Biomaterial Database

Influence of beta-amino-propionitrile on elastogenesis in the chick embryo (light and electron microscopic study). 1978

A Kadar, and A Joos, and H Jellinek

Beta-amino-propionitrile was administered in a single dose into the chorioallantoic cavity of 14 days old chick embryos. The effects on the elastic fibre production were examined on the 3rd or 7th day following the injection. By light microscopy dissecting aneurysm, aortic ruptures were found. The elastic fibres were poorly developed and exhibited irregularities and structural anomalies. Electron microscopically we observed reduction of the number or complete absence of elastic aggregates and fibres. The elastic structures exhibited abnormal phosphotungstic acid binding. This was considered as a sign for disturbances in the development of cross linkages and in the incorporation of elastin into the elastic fibres.

UI	MeSH Term	Description	Entries
D010772	Phosphotungstic Acid	Tungsten hydroxide oxide phosphate. A white or slightly yellowish-green, slightly efflorescent crystal or crystalline powder. It is used as a reagent for alkaloids and many other nitrogen bases, for phenols, albumin, peptone, amino acids, uric acid, urea, blood, and carbohydrates. (From Merck Index, 11th ed)	Acid, Phosphotungstic
D002642	Chick Embryo	The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.	Embryo, Chick,Chick Embryos,Embryos, Chick
D004547	Elastic Tissue	Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.	Elastic Fibers,Elastic Fiber,Elastic Tissues,Fiber, Elastic,Fibers, Elastic,Tissue, Elastic,Tissues, Elastic
D004549	Elastin		alpha-Elastin,kappa-Elastin,alpha Elastin,kappa Elastin
D000629	Aminopropionitrile	Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.	beta-Aminopropionitrile,BAPN,beta Aminopropionitrile
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001011	Aorta	The main trunk of the systemic arteries.	Aortas
D001014	Aortic Aneurysm	An abnormal balloon- or sac-like dilatation in the wall of AORTA.	Aneurysm, Aortic,Aneurysms, Aortic,Aortic Aneurysms
D001019	Aortic Rupture	The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.	Aortic Aneurysm, Ruptured,Ruptured Aortic Aneurysm,Aneurysm, Ruptured Aortic,Aneurysms, Ruptured Aortic,Aortic Aneurysms, Ruptured,Aortic Ruptures,Rupture, Aortic,Ruptured Aortic Aneurysms,Ruptures, Aortic