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The lipid-lowering effect of pantethine, a new drug affecting lipid metabolism, had been evaluated in carbohydrate-induced hyperlipidemic rats. Administration of the drug raised post-heparin lipolytic activities, the change being due to an increase in lipoprotein lipase activity, whereas hepatic lipase activity remained virtually unchanged. Total lipoprotein lipase activity per g of adipose tissue increased in pantethine-treated rats compared with controls. Furthermore, the soluble lipoprotein lipase of fat-pads was fractionated by heparin-Sepharose affinity chromatography. The first active peak, originated from the microsomal fractions, significantly increased after the drug treatment, while the second one, originated from the plasma membranes, remained unchanged. The increase in the microsomal lipoprotein lipase activity may be due to an increase in intracellular synthesis of lipoprotein lipase enzyme proteins. The heterogeneity of lipoprotein lipase of rat adipose tissues was ensured using affinity chromatography on heparin-Sepharose.
A Noma, and
M Kita, and
T Okamiya
April 1984,
Biochemical pharmacology,
A Noma, and
M Kita, and
T Okamiya
January 1988,
Archives of toxicology,
A Noma, and
M Kita, and
T Okamiya
January 1983,
International journal of obesity,
A Noma, and
M Kita, and
T Okamiya
May 1974,
Clinical science and molecular medicine,
A Noma, and
M Kita, and
T Okamiya
December 1980,
European journal of clinical investigation,
A Noma, and
M Kita, and
T Okamiya
January 1991,
Biulleten' eksperimental'noi biologii i meditsiny,
A Noma, and
M Kita, and
T Okamiya
September 1981,
FEBS letters,
A Noma, and
M Kita, and
T Okamiya
May 1979,
Nutrition reviews,
A Noma, and
M Kita, and
T Okamiya
April 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
A Noma, and
M Kita, and
T Okamiya
February 1980,
Biochemical Society transactions,
