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A sensitive method is described for the assay of various biogenic amines and their metabolites from brain tissue homogenates. Based on gas chromatography-mass spectrometry and selected ion monitoring, the method allows reliable low-level quantification of the compounds of interest. By careful study of reaction conditions both in the preparation of derivatives for gas chromatography and in the synthesis of deuterated analogues for internal standard use, relatively simple procedures could be applied with good analytical efficiency. Correlation of the results with those obtained by a high-performance liquid chromatographic procedure was also investigated, and a neurologic application of the method is briefly discussed.
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
November 1974,
Journal of chromatography,
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
December 2013,
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
January 1972,
Analytical biochemistry,
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
January 1990,
Journal of pharmaceutical and biomedical analysis,
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
April 1977,
Analytical biochemistry,
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
January 1992,
Journal of neurochemistry,
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
December 1989,
Journal of neurochemistry,
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
March 1983,
Biomedical mass spectrometry,
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
April 1991,
Journal of chromatography,
J Herranen, and
A Huhtikangas, and
H Tirronen, and
T Halonen, and
M Huuskonen, and
K Reinikainen, and
P Riekkinen
November 1974,
Journal of chromatographic science,
