Application of dynamic mechanical testing to characterize the viscoelastic properties of powder-filled semisolids. 1984

G W Radebaugh, and A P Simonelli

A nondestructive technique, dynamic mechanical testing, was used to characterize the viscoelastic properties of dispersions of powdered starch in anhydrous lanolin. The elastic shear modulus (G'), viscous shear modulus (G"), and loss tangent (damping; tan delta) were determined as a function of shear frequency, temperature, and the volume fraction of starch. The results of these studies show that constitutive mathematical models, derived to predict the mechanical behavior of solid-filled polymeric materials, can be applied to solid-filled semisolid pharmaceuticals. In particular, the Kerner equation was useful in describing the influence of starch on the G' of the dispersions. Even though the Kerner equation was unable to predict viscoelastic behavior at all shear frequencies, temperatures, and starch volume fractions, it proved beneficial in postulating mechanisms for starch-starch and starch-anhydrous lanolin interactions within the dispersions. In addition, damping was able to differentiate the influence of temperature. Data obtained from three temperature ranges, where anhydrous lanolin exists in three different structural states, shows that the influence of starch on damping is dictated by the structural state of anhydrous lanolin.

UI MeSH Term Description Entries
D007809 Lanolin A yellow fat obtained from sheep's wool. It is used as an emollient, cosmetic, and pharmaceutic aid.
D011208 Powders Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed) Powder
D002626 Chemistry, Pharmaceutical Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use. Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D002627 Chemistry, Physical The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes. Physical Chemistry,Chemistries, Physical,Physical Chemistries
D004548 Elasticity Resistance and recovery from distortion of shape.
D013213 Starch Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants. Amylomaize Starch,Amylum,Cornstarch,Keoflo,Starch, Amylomaize
D013696 Temperature The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms. Temperatures
D014783 Viscosity The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Viscosities
D055598 Chemical Phenomena The composition, structure, conformation, and properties of atoms and molecules, and their reaction and interaction processes. Chemical Concepts,Chemical Processes,Physical Chemistry Concepts,Physical Chemistry Processes,Physicochemical Concepts,Physicochemical Phenomena,Physicochemical Processes,Chemical Phenomenon,Chemical Process,Physical Chemistry Phenomena,Physical Chemistry Process,Physicochemical Phenomenon,Physicochemical Process,Chemical Concept,Chemistry Process, Physical,Chemistry Processes, Physical,Concept, Chemical,Concept, Physical Chemistry,Concept, Physicochemical,Concepts, Chemical,Concepts, Physical Chemistry,Concepts, Physicochemical,Phenomena, Chemical,Phenomena, Physical Chemistry,Phenomena, Physicochemical,Phenomenon, Chemical,Phenomenon, Physicochemical,Physical Chemistry Concept,Physicochemical Concept,Process, Chemical,Process, Physical Chemistry,Process, Physicochemical,Processes, Chemical,Processes, Physical Chemistry,Processes, Physicochemical

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