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The authors report the results of a prospective, multi-centre trial involving 87 patients with previously untreated myeloma who were treated by combination chemotherapy consisting of melphalan, cyclophosphamide, CCNU, prednisone and vincristine. 83.1% of patients had a high tumour mass (stage III on Durie and Salmon's classification). The response to treatment could be evaluated in 76 patients and 70% were found to respond. The median actuarial survival of the whole population is 30 months. The survival is significantly longer (p less than 0.001) in responders (median 40 months) than in non-responders (median: 17 months); the survival is significantly shorter (p less than 0.01) in subjects with renal failure (median: 10 months) than in subjects without renal failure (median: 36 months). This treatment is sufficiently well tolerated to be administered on an outpatient basis. One case of acute monoblastic leukaemia was observed. These results are similar to those reported in the literature.
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
January 1985,
Oncology,
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
November 1982,
Cancer treatment reports,
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
January 1984,
The Netherlands journal of medicine,
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
January 1981,
Archivum immunologiae et therapiae experimentalis,
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
July 1984,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
December 1986,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
June 1987,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
January 1988,
Oncology,
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
August 1989,
Cancer,
X Le Loët, and
M Monconduit, and
J F Menard, and
P Deshayes, and
B Grobois, and
A Tanguy, and
E Prevost, and
H Piguet
May 1982,
Blood,
