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The effect of orally-administered stanozolol, 5 mg b.d. on fibrinolysis, coagulation and on various haematological and biochemical parameters have been studied in 16 healthy adults, 8 males and 8 females. Statistically significant enhancement of extrinsic (tissue-type) plasminogen activator activity was detected in all subjects studied. This was associated with significant increases in plasma plasminogen and a concomitant reduction in histidine-rich glycoprotein. There were no changes in plasma urokinase activity. Changes in the coagulation system included significant reduction in plasma fibrinogen and elevation of protein C and antithrombin III. Changes in plasma lipids included significant reduction of HDL cholesterol associated with an increase in LDL triglycerides. No change occurred in total cholesterol. There were no major differences between the sexes, nor were there serious side effects. The effects of stanozolol on extrinsic (tissue-type) plasminogen activator activity, "free" plasminogen, protein C and antithrombin III, argue strongly in favour of its therapeutic potential.
C Kluft, and
F E Preston, and
R G Malia, and
R M Bertina, and
G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
January 2003,
Sports medicine (Auckland, N.Z.),
C Kluft, and
F E Preston, and
R G Malia, and
R M Bertina, and
G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
February 1971,
Zentralblatt fur Chirurgie,
C Kluft, and
F E Preston, and
R G Malia, and
R M Bertina, and
G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
December 2006,
Journal of laparoendoscopic & advanced surgical techniques. Part A,
C Kluft, and
F E Preston, and
R G Malia, and
R M Bertina, and
G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
December 1986,
Masui. The Japanese journal of anesthesiology,
C Kluft, and
F E Preston, and
R G Malia, and
R M Bertina, and
G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
January 1973,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
C Kluft, and
F E Preston, and
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G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
April 1995,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
C Kluft, and
F E Preston, and
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R M Bertina, and
G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
March 1989,
Der Nervenarzt,
C Kluft, and
F E Preston, and
R G Malia, and
R M Bertina, and
G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
September 1990,
American journal of veterinary research,
C Kluft, and
F E Preston, and
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R M Bertina, and
G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
March 2003,
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue,
C Kluft, and
F E Preston, and
R G Malia, and
R M Bertina, and
G Wijngaards, and
M Greaves, and
J H Verheijen, and
G Dooijewaard
December 1991,
Nihon rinsho. Japanese journal of clinical medicine,
