Acute exposure to methyl or ethyl alcohol alters auditory function in the rat. 1984

J R Wecker, and J R Ison

Effects of alcohol on audition were studied in the rat by examining the modification of acoustic startle reflexes by pure tone pulses and by gaps in white noise. Systematic inhibition of the startle reflex by variation in pulse intensity provides an objective measure of loudness perception, while variation in gap duration assesses temporal acuity. Groups of rats (n = 8) received four injections of 0.0, 0.25, 1.00, and 2.00 g/kg of either methyl or ethyl alcohol in increasing order at 1-hr intervals. One-half hour after the administration of each dose, loudness perception or temporal acuity was measured. Blood alcohol levels (mM) for the two alcohols obtained in control animals were equivalent following the final dose. Alcohol produced a dose-dependent reduction in baseline startle amplitude that was greater during exposure to ethanol than during methanol. Loudness functions associated with pulse intensity were not diminished by alcohol; however, inhibition produced by a gap in noise was reduced following the highest dose of either alcohol. These data are consistent both with behavioral studies that have suggested that alcohol does not affect loudness perception, and with electrophysiological experiments which indicate that alcohol disrupts temporal relationships along the primary auditory pathway.

UI MeSH Term Description Entries
D008144 Loudness Perception The perceived attribute of a sound which corresponds to the physical attribute of intensity. Loudness Perceptions,Perception, Loudness,Perceptions, Loudness
D008297 Male Males
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D011930 Reaction Time The time from the onset of a stimulus until a response is observed. Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females
D006311 Hearing Disorders Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices, including the sensorineural pathways. Distorted Hearing,Dysacusis,Paracousis,Paracusis,Hearing Disorder,Hearing, Distorted
D000161 Acoustic Stimulation Use of sound to elicit a response in the nervous system. Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000432 Methanol A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness. Alcohol, Methyl,Carbinol,Sodium Methoxide,Wood Alcohol,Alcohol, Wood,Methoxide, Sodium,Methyl Alcohol

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