Biomaterial Database

Hydrolysis of pyrethroid insecticides by soluble mouse brain esterases. 1984

S M Ghiasuddin, and D M Soderlund

trans-Permethrin, a pyrethroid insecticide, was hydrolyzed by one or more carboxylesterases located in the soluble fraction of mouse brain homogenates. The apparent affinity of this activity for trans-permethrin was greater than that reported for mouse hepatic carboxylesterase activity, but the apparent maximum velocity was considerably lower than that of the hepatic activity. Soluble brain esterases also hydrolyzed several other pyrethroid esters with a substrate specificity different from that of the hepatic esterases. In particular, alpha-cyano-3-phenoxybenzyl esters of noncyclopropane acids (e.g., fenvalerate and fluvalinate) were hydrolyzed by brain esterases at rates equal to or greater than that measured for trans-permethrin. These results suggest that hydrolysis in the brain may contribute to the detoxication of some pyrethroids in mammals.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008813	Mice, Inbred ICR	An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER.	Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D009570	Nitriles	Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.	Nitrile
D011722	Pyrethrins	The active insecticidal constituent of CHRYSANTHEMUM CINERARIIFOLIUM flowers. Pyrethrin I is the pyretholone ester of chrysanthemummonocarboxylic acid and pyrethrin II is the pyretholone ester of chrysanthemumdicarboxylic acid monomethyl ester.	Pyrethrin,Pyrethroid,Pyrethroids
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D004950	Esterases	Any member of the class of enzymes that catalyze the cleavage of an ester bond and result in the addition of water to the resulting molecules.	Esterase
D006868	Hydrolysis	The process of cleaving a chemical compound by the addition of a molecule of water.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D026023	Permethrin	A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.	Cyclopropanecarboxylic Acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (3-phenoxyphenyl)methyl ester,(m-Phenoxybenzyl)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate,3-Phenoxybenzyl-(+-)-cis,trans-2,2-dichlorovinyl-2,2-dimethyl-cyclopropylcarboxylic acid, ester,3-Phenoxybenzyl-cis,trans-(1RS)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate,Ambush,Elimite,FMC-33297,NIA-33297,NRDC-143,NRDC-147,Nittifor,PP-557,Permethrin, (1R-cis)-Isomer,Permethrin, (1R-trans)-Isomer,Permethrin, (1S-cis)-Isomer,Permethrin, (1S-trans)-Isomer,Permethrin, (cis)-Isomer,Permethrin, (cis-(+-))-Isomer,Permethrin, (trans)-Isomer,Permethrin, (trans-(+-))-Isomer,Permethrin, trans-(1RS)-Isomer,S-3151,cis-(1RS)-permethrin,cis-permethrin,permethrin, cis-(1RS)-isomer,trans-(1RS)-Permethrin,trans-permethrin,FMC 33297,FMC33297,NIA 33297,NIA33297,NRDC 143,NRDC 147,NRDC143,NRDC147,PP 557,PP557,S 3151,S3151,cis permethrin,trans permethrin