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Male Wistar rats kept for 30 days on the diet containing vegetative (wheat) protein demonstrate an increase in cytochrome P-450 concentration in liver microsomes and an increase in the rate of amidopyrine N-demethylation and aniline p-hydroxylation. Administration of phenobarbital leads to cytochrome P-450 induction and activation of monooxygenase of rat liver microsomes, the quality of food protein not affecting cytochrome induction. It is assumed that high content of cytochrome P-450 is linked with prolongation of the time of cytochrome P-450 renewal at the expense of the decreased constant of its protein part degradation or with activation of cytochrome synthesis de novo (based on the preliminary data).
T N Zaboikina, and
M M Gapparov
January 1984,
Eksperimentalna meditsina i morfologiia,
T N Zaboikina, and
M M Gapparov
July 1983,
Die Pharmazie,
T N Zaboikina, and
M M Gapparov
January 1990,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
T N Zaboikina, and
M M Gapparov
December 1957,
Acta vitaminologica,
T N Zaboikina, and
M M Gapparov
July 1984,
Xenobiotica; the fate of foreign compounds in biological systems,
T N Zaboikina, and
M M Gapparov
January 1985,
Farmakologiia i toksikologiia,
T N Zaboikina, and
M M Gapparov
May 1987,
Age and ageing,
T N Zaboikina, and
M M Gapparov
October 1983,
Laboratory animals,
T N Zaboikina, and
M M Gapparov
January 1975,
Nutrition and metabolism,
T N Zaboikina, and
M M Gapparov
June 1976,
Chemico-biological interactions,
