On 144 patients with an average age of 47.1 years who were admitted to a four-week cure for heart and circulation the changed behaviour of heart and circulation at rest and under submaximal load by means of ergometry was assessed according to the variability of the pulse rate, the arterial blood pressure and the maximal volume of oxygen intake (VO2 max). A four-week training in perseverance run--performed according to several training impulses--effects a bradycardization, improvement in the patient's physical health (VO2 max) and a decrease of initially increased systolic and diastolic blood pressure values. A daily perseverance training of 60 min with intensities about 50% VO2 max is the most effective and also well applicable and dosable training impulse for older and less efficient persons during cure. The cardiac volume (size of the heart) does not show an ascertained change after cure.