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Morpho-functional development of the cerebral cortex of newborn rats and the influence of noradrenaline (NA) on this process was investigated under the conditions of long-term (up to 41 days) organotypical tissue cultivation. Systematic adding of NA to the nutrient medium in the process of explants cultivation was shown to disturb its structural organization, to depress proliferation of the glia, synaptogenesis and axon myelinization. Decrease of number of spontaneously active neurones by 30% and predominance of neurones with periodical discharges (bursts or groups) was observed in all periods of cultivating in NA presence. Development of neurones in the NA containing medium changed their sensitivity to NA which became close to that in situ.
A R Chubakov, and
E I Chumasov, and
E A Gromova, and
G V Konovalov, and
V G Tsyganova
January 1974,
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A R Chubakov, and
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E A Gromova, and
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V G Tsyganova
July 1985,
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A R Chubakov, and
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January 1990,
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A R Chubakov, and
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G V Konovalov, and
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Toxicology letters,
A R Chubakov, and
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E A Gromova, and
G V Konovalov, and
V G Tsyganova
June 1993,
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A R Chubakov, and
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G V Konovalov, and
V G Tsyganova
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A R Chubakov, and
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G V Konovalov, and
V G Tsyganova
January 1980,
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A R Chubakov, and
E I Chumasov, and
E A Gromova, and
G V Konovalov, and
V G Tsyganova
January 1980,
Voprosy meditsinskoi khimii,
A R Chubakov, and
E I Chumasov, and
E A Gromova, and
G V Konovalov, and
V G Tsyganova
January 1979,
Voprosy meditsinskoi khimii,
