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Implants of crystalline PGE2 in the basal preoptic-anterior hypothalamic areas stimulates high levels of sexual receptivity in ovariectomized, estrogen-primed rats. Indomethacin, which blocks the synthesis of PGE2 failed to inhibit either estrogen- or estrogen plus progesterone-induced receptivity. Neither intracerebral nor subcutaneous administration of indomethacin diminished the display of steroid induced reproductive behavior without also causing a depression in open-field activity, and in some cases, causing gastrointestinal problems and even death. These results suggest the prostaglandin synthesis is not a required step in the mechanism by which estrogen and progesterone exert their behavioral effects. The possibility that PGE2 and LH-RH synthesis and/or release might contribute to a collateral mechanism for the induction of sexual receptivity was discussed.
N R Hall, and
W G Luttge
June 1978,
The Journal of endocrinology,
N R Hall, and
W G Luttge
December 1997,
Hormones and behavior,
N R Hall, and
W G Luttge
December 1977,
Pharmacology, biochemistry, and behavior,
N R Hall, and
W G Luttge
April 1983,
Pharmacology, biochemistry, and behavior,
N R Hall, and
W G Luttge
January 1975,
Neuroendocrinology,
N R Hall, and
W G Luttge
April 1972,
Physiology & behavior,
N R Hall, and
W G Luttge
February 1975,
Steroids,
N R Hall, and
W G Luttge
October 1977,
Endocrinology,
N R Hall, and
W G Luttge
July 1978,
Pharmacology, biochemistry, and behavior,
N R Hall, and
W G Luttge
June 1972,
Behavioral biology,
