-transparent.png){kind=logo}
Two insulin dependent diabetics with previous anaphylactic like (anaphylactoid) reactions to protamine underwent successful cardiopulmonary bypass for coronary artery surgery. Platelet concentrates instead of protamine were used to neutralise their systemic heparinisation. In both cases the anaphylactoid reactions first became apparent after administration of protamine sulphate at the end of cardiac catheterisation. These cases show that adverse reactions to protamine need not be a contraindication to cardiopulmonary bypass and cardiac surgery and emphasise that this condition should be considered in all patients with a history of previous protamine exposure or one which may be associated with anaphylactoid reactions to protamine.
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
November 1996,
Anesthesiology,
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
May 1985,
British heart journal,
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
January 1976,
Anesthesia and analgesia,
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
March 1983,
Anaesthesia,
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
December 2022,
Perfusion,
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
April 1983,
The Journal of thoracic and cardiovascular surgery,
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
April 2013,
Blood,
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
October 1998,
The Thoracic and cardiovascular surgeon,
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
October 2018,
Journal of thrombosis and haemostasis : JTH,
W S Walker, and
K G Reid, and
C F Hider, and
I A Davidson, and
F E Boulton, and
P L Yap
September 1974,
Thorax,
