-transparent.png){kind=logo}
The promoting effects of ascorbic acid, sodium erythorbate and ethoxyquin on two-stage urinary bladder carcinogenesis in F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at a dose of 0.05% in the drinking water were examined. Administration of 5% sodium erythorbate in the diet significantly increased the incidences of preneoplastic lesions, papilloma and cancer of the urinary bladder, whereas administration of 5% ascorbic acid in the diet did not. Administration of 0.8% ethoxyquin also increased the incidence of neoplastic lesions. Administrations of 5% sodium L-ascorbate and 5% sodium erythorbate caused increases in the pH, the sodium content and crystals of MgNH4PO4 in the urine. These results show that sodium erythorbate and ethoxyquin promote urinary bladder carcinogenesis, while ascorbic acid does not.
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
December 1980,
Gan,
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
November 1984,
Gan,
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
June 1994,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
October 1994,
Carcinogenesis,
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
January 1986,
Urological research,
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
June 1988,
Cancer letters,
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
January 1992,
Voprosy onkologii,
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
January 1993,
Teratogenesis, carcinogenesis, and mutagenesis,
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
January 1987,
Urologia internationalis,
S Fukushima, and
Y Kurata, and
M Shibata, and
E Ikawa, and
N Ito
January 1999,
Teratogenesis, carcinogenesis, and mutagenesis,
