Biomaterial Database

Immunological abnormalities in the tonsils of patients with IgA nephropathy: inversion in the ratio of IgA: IgG bearing lymphocytes and increased polymeric IgA synthesis. 1984

J Egido, and R Blasco, and L Lozano, and J Sancho, and R Garcia-Hoyo

In the last few years the mucosal origin of the IgA deposited in the kidneys of patients with IgA nephropathy has been examined by several investigators. We have previously presented evidence that polymeric IgA may have a predominant role in the pathogenesis of IgA nephropathy. Taking into account that these patients often present with macroscopic haematuria following respiratory tract infections we have studied the possible existence of immunological abnormalities in the tonsils of patients with IgA nephropathy. Six patients and 13 controls suffering from chronic tonsillitis were submitted to tonsillectomy. Patients with IgA nephropathy showed a significant increase (P less than 0.00025) in IgA bearing lymphocytes (14.4 +/- 2.3) and a significant decrease (P less than 0.025) in IgG bearing lymphocytes (20.5 +/- 4.6) compared to the control group (2.9 +/- 1.4 and 31.6 +/- 3.6, respectively). After 7 days of culture with pokeweed mitogen the percentage of tonsillar cells producing polymeric IgA was significantly higher in the patients than in the controls (66.5 +/- 12.6 vs 33.4 +/- 10.3; P less than 0.005). These results also suggest a mucosal origin for the IgA deposited in the kidneys of these patients. Our data are consistent with the existence of an immunoregulatory dysfunction in the secretory immune system of patients with IgA nephropathy.

UI	MeSH Term	Description	Entries
D007070	Immunoglobulin A	Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.	IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007074	Immunoglobulin G	The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.	Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007674	Kidney Diseases	Pathological processes of the KIDNEY or its component tissues.	Disease, Kidney,Diseases, Kidney,Kidney Disease
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008297	Male		Males
D011043	Pokeweed Mitogens	Proteins isolated from the roots of the pokeweed, Phytolacca americana, that agglutinate some erythrocytes, stimulate mitosis and antibody synthesis in lymphocytes, and induce activation of plasma cells.	Lectins, Pokeweed,Pokeweed Lectin,Pokeweed Lectins,Pokeweed Mitogen,Pokeweed Mitogen Isolectin,Isolectin, Pokeweed Mitogen,Lectin, Pokeweed,Mitogen Isolectin, Pokeweed,Mitogen, Pokeweed,Mitogens, Pokeweed
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D003593	Cytoplasm	The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)	Protoplasm,Cytoplasms,Protoplasms
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man