Biomaterial Database

Disturbance of recent memory function in parkinsonian patients on anticholinergic therapy. 1984

W C Koller

Disruption of cholinergic neurotransmission may result in memory impairment. In this study the anticholinergic drug, trihexyphenidyl, at low doses when administered chronically for one month to Parkinson disease patients caused a decrease in performance on recent but not immediate memory tests. Awareness of possible deterioration of memory function of parkinsonian patients on anticholinergic medication is necessary.

UI	MeSH Term	Description	Entries
D008568	Memory	Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D010153	Paired-Associate Learning	Learning in which the subject must respond with one word or syllable when presented with another word or syllable.	Learning, Paired-Associate,Learnings, Paired-Associate,Paired Associate Learning,Paired-Associate Learnings
D010300	Parkinson Disease	A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)	Idiopathic Parkinson Disease,Lewy Body Parkinson Disease,Paralysis Agitans,Primary Parkinsonism,Idiopathic Parkinson's Disease,Lewy Body Parkinson's Disease,Parkinson Disease, Idiopathic,Parkinson's Disease,Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinsonism, Primary
D011939	Mental Recall	The process whereby a representation of past experience is elicited.	Recall, Mental
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D014282	Trihexyphenidyl	One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.	Benzhexol,Apo-Trihex,Artane,Cyclodol,Hipokinon,Parkinane,Parkopan,Trihexane,Trihexidyl Hydrochloride,Trihexyphenidyl Hydrochloride,Trihexyphenidyl Hydrochloride Elixir,Apo Trihex,ApoTrihex
D014706	Verbal Learning	Learning to respond verbally to a verbal stimulus cue.	Learning, Verbal,Learnings, Verbal,Verbal Learnings