Biomaterial Database

Spectrophotometric determination of bromhexine hydrochloride in pharmaceutical preparations. 1984

M I Santoro, and M M dos Santos, and J F Magalhães

The presence of an aromatic primary amino group in bromhexine HCl enables the use of diazotization-coupling, according to the classic Bratton-Marshall method, for its analysis in pharmaceutical preparations. Spectrophotometric parameters were established for standardization of the method, including statistical analysis of data. Substances such as potassium guaiacolsulfonate, ampicillin, cephalexin, oxytetracycline HCl, amoxycillin, and erythromycin ethylsuccinate do not interfere with the determination. The precision of the method is about 2.0%.

UI	MeSH Term	Description	Entries
D010592	Pharmaceutic Aids	Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.	Aids, Pharmaceutic,Aids, Pharmaceutical,Pharmaceutical Aids
D001964	Bromhexine	A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)	Aparsonin,Bisolvon,Bromhexin,Bromhexin BC,Bromhexin Berlin-Chemie,Bromhexin-ratiopharm,Bromhexine Hydrochloride,Bromhexine Monohydrochloride,Brotussol,Darolan,Dur-Elix,Famel Bromhexine,Flegamin,Flubron,Hustentabs-ratiopharm,Mucohexine,NA-274,Quentan,Tesacof,bromhexin von ct,BC, Bromhexin,Bromhexin Berlin Chemie,Bromhexin BerlinChemie,Bromhexin ratiopharm,Bromhexine, Famel,Bromhexinratiopharm,Dur Elix,DurElix,Hustentabs ratiopharm,Hustentabsratiopharm,Hydrochloride, Bromhexine,Monohydrochloride, Bromhexine,NA 274,NA274,ct, bromhexin von,von ct, bromhexin
D002214	Capsules	Hard or soft soluble containers used for the oral administration of medicine.	Capsule,Microcapsule,Microcapsules
D012996	Solutions	The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)	Solution
D013053	Spectrophotometry	The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
D013535	Suspensions	Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.	Suspension
D013607	Tablets	Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)	Tablet