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First investigations on the therapeutic activity of a new group of steroid-linked N-(2-chloroethyl)-N-nitrosocarbamoyl-L-alanine esters (CNC-L-alanine esters) in a nitrosourea-sensitive rat leukemia (L 5222) characterized by a relatively high content of glucocorticoid binding sites are presented. Despite a considerable range of optimal and toxic doses of the different analogs, the respective therapeutic ratios do not appear to be significantly influenced by the nature of the carrier molecules to which CNC-L-alanine is attached. However several steroid-linked representatives are distinctly more active than CNC-L-alanine. The androsterone-3-ester and the dihydrotestosterone-17-ester, in particular effected high percentages of cures in contrast to CNC-L-alanine.
W J Zeller, and
J Schreiber, and
A D Ho, and
D Schmähl, and
G Eisenbrand
December 1989,
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W J Zeller, and
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G Eisenbrand
January 2008,
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W J Zeller, and
J Schreiber, and
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G Eisenbrand
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W J Zeller, and
J Schreiber, and
A D Ho, and
D Schmähl, and
G Eisenbrand
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W J Zeller, and
J Schreiber, and
A D Ho, and
D Schmähl, and
G Eisenbrand
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W J Zeller, and
J Schreiber, and
A D Ho, and
D Schmähl, and
G Eisenbrand
June 1976,
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W J Zeller, and
J Schreiber, and
A D Ho, and
D Schmähl, and
G Eisenbrand
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W J Zeller, and
J Schreiber, and
A D Ho, and
D Schmähl, and
G Eisenbrand
January 1990,
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W J Zeller, and
J Schreiber, and
A D Ho, and
D Schmähl, and
G Eisenbrand
January 1988,
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W J Zeller, and
J Schreiber, and
A D Ho, and
D Schmähl, and
G Eisenbrand
January 1981,
Cancer treatment reports,
