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The provocative dose of inhaled methacholine required to cause a 20% drop in the forced expiratory volume in 1 sec was evaluated in two selected pediatric populations. On the basis of a standardized respiratory questionnaire, 165 individuals 5 to 21 yr of age were identified. Included were 110 normal nonatopic individuals and 55 current asthmatic subjects. Methacholine inhalation challenges were performed by use of a standard inhalation procedure. Fifty-four (98.1%) of the asthmatic subjects responded to methacholine with a 20% drop in the forced expiratory volume in 1 sec. Seventy (63.1%) of the normal individuals did not respond to methacholine. The specificity and sensitivity of the methacholine challenge was best obtained at a provocative dose of 100 breath units of methacholine.
R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
September 1986,
Acta paediatrica Scandinavica,
R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
September 1985,
Arerugi = [Allergy],
R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
June 1998,
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R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
April 2002,
Anales espanoles de pediatria,
R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
November 1994,
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R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
December 1979,
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R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
February 1969,
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R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
October 1988,
Arerugi = [Allergy],
R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
August 1992,
Acta paediatrica Japonica : Overseas edition,
R J Hopp, and
A K Bewtra, and
N M Nair, and
R G Townley
January 1997,
The Turkish journal of pediatrics,
