Biomaterial Database

Tissue distribution and excretion of 14C-epichlorohydrin in male and female rats. 1978

W W Weigel, and H B Plotnick, and W L Conner

The tissue distribution and excretion of 14C-epichlorohydrin was studied in both male and female rats following an oral dose of 10 mg/kg. Organs containing the highest concentrations of radioactive label per unit weight were the kidneys, liver, pancreas, ann spleen. With the exception of the pancreas, these are the same organs in which epichlorohydrin-induced pathologic changes have been reported by a number of investigators, indicating a direct correlation between tissue levels and target organ toxicity. The principal route of excretion was via the kidneys, 38-40% of the dose appearing in the urine during the 72 hour period of study. Fecal excretion was relatively insignificant, representing less than 4% of the administered dose. It was found that 18-21% of the administered dose appeared as 14CO2 in the expired air, the majority being excreted in the first 4 hours, suggesting a rapid and extensive biotransformation of the compound.

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D008297	Male		Males
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D002728	Chlorohydrins	Any of the compounds derived from a group of glycols or polyhydroxy alcohols by chlorine substitution for part of the hydroxyl groups. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)	Chlorhydrins
D004811	Epichlorohydrin	A chlorinated epoxy compound used as an industrial solvent. It is a strong skin irritant and carcinogen.	Epichlorhydrin,Epichlorohydrin, (+-)-Isomer,Epichlorohydrin, (S)-Isomer
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D012737	Sex Factors	Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.	Factor, Sex,Factors, Sex,Sex Factor
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor