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The effects of chronic administration of haloperidol and chlordiazepoxide for 14 days on self-stimulation behavior were investigated in rats with electrodes chronically implanted in the lateral hypothalamus. Haloperidol produced a prominent decrease in self-stimulation behavior during chronic treatment, followed by a significant increase in the lever-pressing rate during a 2 week withdrawal period, with a return to the control level about 5 weeks after drug withdrawal. Chlordiazepoxide produced a significant increase in self-stimulation behavior during chronic treatment. However, the lever-pressing rate was not significantly different from the control level during a 3 week observation period following drug withdrawal. These results indicate an increase in the sensitivity of central dopaminergic receptors following chronic haloperidol treatment, but not following chronic chlordiazepoxide treatment.
T Fukuda, and
T Tsumagari
May 1985,
Physiology & behavior,
T Fukuda, and
T Tsumagari
January 1983,
Psychopharmacology,
T Fukuda, and
T Tsumagari
October 1978,
Life sciences,
T Fukuda, and
T Tsumagari
September 1970,
Physiology & behavior,
T Fukuda, and
T Tsumagari
December 1977,
Pharmacology, biochemistry, and behavior,
T Fukuda, and
T Tsumagari
August 1974,
Japanese journal of pharmacology,
T Fukuda, and
T Tsumagari
January 1972,
Revue canadienne de biologie,
T Fukuda, and
T Tsumagari
May 1976,
Brain research,
T Fukuda, and
T Tsumagari
September 1967,
Science (New York, N.Y.),
T Fukuda, and
T Tsumagari
January 1984,
Physiology & behavior,
