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Two samples of 4-amino-2-nitrophenol were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100. Significant mutagenic activity was detected with a sample of this compound obtained from Aldrich (technical grade (Aldrich), TGA) both in the presence and in the absence of a rat-liver S9 metabolic activation mixture. When toluene-insoluble contaminants of the TGA product were separated and tested for mutagenicity, they were found to be mutagenic in the same strains as the TGA sample. After removal of these major contaminants from the TGA product its mutagenicity was reduced; a nonmutagenic sample was obtained by further purification. The other sample of 4-amino-2-nitrophenol, which was synthesized and purified in our laboratory, was nonmutagenic. H.p.l.c. profiles of the unpurified TGA sample and the purified samples revealed a large number of contaminants in the TGA product. Likewise, t.l.c. revealed the presence of contaminants in the TGA product.
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
January 1978,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man,
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
January 1993,
IARC monographs on the evaluation of carcinogenic risks to humans,
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
November 1983,
Biochimica et biophysica acta,
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
December 1982,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
November 1985,
Journal of chromatography,
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
January 1978,
National Cancer Institute carcinogenesis technical report series,
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
January 2002,
Sudebno-meditsinskaia ekspertiza,
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
June 2019,
Bulletin of environmental contamination and toxicology,
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
January 1993,
IARC monographs on the evaluation of carcinogenic risks to humans,
M M Shahin, and
A Bugaut, and
A Junino, and
G Kalopissis
April 2001,
Mutation research,
