BIOMAT Database Logo BIOMAT Database Logo

Protriptyline in obstructive sleep apnea: a double-blind trial. 1982

L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger

We evaluated protriptyline, a nonsedating tricyclic antidepressant, as a treatment for obstructive sleep apnea in a double-blind crossover study of five men. After two weeks of treatment, with no change in body weight, daytime somnolence was markedly reduced and nocturnal oxygenation was improved, although apnea duration and frequency were not significantly decreased. Rapid-eye-movement (REM) stage time as a fraction of the total sleep time was reduced during treatment from 0.231 +/- 0.031 to 0.107 +/- 0.013 (mean +/- S.E.M.) (P less than 0.05). REM apnea time as a fraction of total sleep time was reduced from 0.145 +/- 0.022 to 0.054 +/- 0.006 (P less than 0.05). REM reduction during treatment with protriptyline can account for decreased REM apnea time. Similar decreases in REM stage time and REM apnea duration and similar improvement in oxygenation continued after six months of treatment. In addition, body weight, apnea, and arousal frequency were decreased at this time. Although the obstructive sleep apnea was not resolved, it was reduced. Protriptyline can be effective in patients with sleep apnea when the disorder is not life-threatening.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D011530 Protriptyline Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation. Protriptyline Hydrochloride,Vivactil,Hydrochloride, Protriptyline
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic
D003986 Dibenzocycloheptenes A family of tricyclic hydrocarbons whose members include many of the commonly used tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC).
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
A double-blind trial of protriptyline in the treatment of sleep apnea syndrome.
January 1988, Henry Ford Hospital medical journal,
L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
Theophylline in obstructive sleep apnea. A double-blind evaluation.
March 1992, Chest,
L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
A double-blind, randomized trial of sabeluzole--a putative glutamate antagonist--in obstructive sleep apnea.
May 1996, Sleep,
L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
Response of obstructive sleep apnea to fluoxetine and protriptyline.
August 1991, Chest,
L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
Treatment of obstructive sleep apnea with CPAP and protriptyline.
December 1988, Chest,
L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
Beneficial effect of donepezil on obstructive sleep apnea: a double-blind, placebo-controlled clinical trial.
March 2012, Sleep medicine,
L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
Montelukast for Children with Obstructive Sleep Apnea: Results of a Double-Blind, Randomized, Placebo-Controlled Trial.
October 2016, Annals of the American Thoracic Society,
L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
Sleep apnea: treatment with protriptyline.
September 1979, Neurology,
L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
A double-blind, placebo-controlled, crossover study of sildenafil in obstructive sleep apnea.
September 2006, Archives of internal medicine,
L G Brownell, and P West, and P Sweatman, and J C Acres, and M H Kryger
Effects of respiratory exercises in sleep bruxism and associated obstructive sleep apnea: a double-blind, placebo-controlled randomized clinical trial.
April 2024, Acta odontologica Scandinavica,
Copied contents to your clipboard!