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In 13 type II hyperlipidemics (10 males and 3 females; mean age 50.2 +/- 10.6 years), in 10 type IV hyperlipidemics (7 males and 3 females; mean age 51 +/- 13.3 years) and in 23 healthy age- and sex-matched controls, the following parameters were measured: plasma cholesterol; plasma TG; plasma C-HDL; VLDL, separated in a preparative ultracentrifuge; C-LDL; Apo B, with immunoelectrophoretic method; platelet sensitivity to prostacyclin; TXB2 formation in PRP; TXB2 in serum. This study provides evidence for: 1. Reduced platelet sensitivity to prostacyclin, more evident in type II hyperlipidemia that provides an additional mechanism involved in increased platelet aggregation found in type II hyperlipidemia. 2. Enhanced TXB2 formation in PRP after thrombin stimulation (664.65 +/- 142.18 pmol/10(8) platelets) only in type II hyperlipidemics and such enhanced formation was positively correlated to C-LDL (r = 0.53; p less than 0.05) and to Apo B (r = 0.62; p less than 0.05); serum TXB2 formation rate was also increased in type II hyperlipidemia.
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
June 1982,
Thrombosis and haemostasis,
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
January 1991,
Arteriosclerosis and thrombosis : a journal of vascular biology,
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
December 1981,
Thrombosis and haemostasis,
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
June 1981,
Thrombosis and haemostasis,
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
January 1995,
Platelets,
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
August 1982,
Toxicology and applied pharmacology,
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
October 1983,
Lancet (London, England),
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
January 1989,
Eicosanoids,
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
July 1992,
Prostaglandins, leukotrienes, and essential fatty acids,
A Strano, and
G Davì, and
M Averna, and
G B Rini, and
S Novo, and
G Di Fede, and
A Mattina, and
A Notarbartolo
January 1983,
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement,
