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The quantitative relationship between carcinogenicity in rodents and mutagenicity in S. typhimurium was examined using 10 monofunctional alkylating agents, including N-nitrosamides, alkylmethane sulfonates and epoxides. The compounds were assayed for mutagenicity in two S. typhimurium strains (TA1535, TA100) and in plate and liquid assays. Mutagenic activity was compared with alkylating activity, half-life (solvolysis constant) and carcinogenic activity in rodents (TD50). No correlations between these variables were found. However, there was a good positive relationship between the TD50 values of the carcinogens and the initial ratios of N-7-alkylguanine to 0(6)-alkylguanine formed after reaction with double-stranded DNA in vitro (r = 0.88, p less than 0.01; n = 9). From these results, it is concluded that the N-7/0(6)-alkylguanine ratio is quantitatively related to the carcinogenic activity for this class of compounds and it may therefore be used to predict the carcinogenic potency of new compounds within this class.
H Bartsch, and
C Malaveille, and
L Tomatis, and
G Brun, and
B Dodet, and
B Terracini
January 1987,
Molecular toxicology,
H Bartsch, and
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L Tomatis, and
G Brun, and
B Dodet, and
B Terracini
January 1976,
Annales de la nutrition et de l'alimentation,
H Bartsch, and
C Malaveille, and
L Tomatis, and
G Brun, and
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B Terracini
December 1968,
Food and cosmetics toxicology,
H Bartsch, and
C Malaveille, and
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G Brun, and
B Dodet, and
B Terracini
January 1998,
Mutation research,
H Bartsch, and
C Malaveille, and
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G Brun, and
B Dodet, and
B Terracini
January 1991,
IARC scientific publications,
H Bartsch, and
C Malaveille, and
L Tomatis, and
G Brun, and
B Dodet, and
B Terracini
January 1976,
IARC scientific publications,
H Bartsch, and
C Malaveille, and
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G Brun, and
B Dodet, and
B Terracini
January 1988,
Mutation research,
H Bartsch, and
C Malaveille, and
L Tomatis, and
G Brun, and
B Dodet, and
B Terracini
January 1986,
Journal of medicinal chemistry,
H Bartsch, and
C Malaveille, and
L Tomatis, and
G Brun, and
B Dodet, and
B Terracini
January 1979,
Journal of the National Cancer Institute,
H Bartsch, and
C Malaveille, and
L Tomatis, and
G Brun, and
B Dodet, and
B Terracini
January 1980,
Journal of toxicology and environmental health,
