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Inhibitory effects of TN-762 (suprofen), ketoprofen, and indomethacin on rat or rabbit platelet aggregation were examined. Of these compounds tested, Suprofen showed the most potent effect on platelet aggregation in vitro, especially in AA-induced rabbit platelet aggregation (IC50 = 0.01 microM). Suprofen showed an inhibitory effect similar to that of ketoprofen and indomethacin on rat platelet aggregation ex vivo. The lethal effect of AA in the rabbits was protected by suprofen (0.05 mg/kg p.o.) at concentrations lower than the other compounds. Similar to the compounds, suprofen had little effect on the PG I2 synthesis in the rat aorta. In order to test the direct effects of these compounds on the platelet avoiding the effects of other plasma components, gel-filtrated rat platelets were used. All tested compounds showed similar inhibitory effect. To investigating the interaction of these compounds with the lipid bilayers, we used the liposome as a model membrane. The tested compounds inhibited liposome aggregation induced by 4 mM Ca2+. In this experiment, the interaction of suprofen with the lipid bilayers was shown.
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
November 1993,
Thrombosis and haemostasis,
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
February 2000,
Thrombosis research,
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
July 2014,
Journal of agricultural and food chemistry,
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
July 2012,
Natural product communications,
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
January 1980,
Thrombosis research,
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
March 1994,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
February 1987,
Thrombosis research,
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
June 1987,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
September 2010,
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,
H Imai, and
Y Muramatsu, and
K Niu, and
M Nozaki, and
H Fujimura
March 1992,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
