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A transepidermal chemotherapy of onchocerciasis. 1978

M E Langham, and Z D Traub, and R Richardson

Counts of microfilariae in the skin, and histological and electronmicroscopic procedures have been used to analyze the response of onchocerciasis patients to diethylcarbamazine citrate (DEC) given either orally or topically. Oral administration of DRC failed to eliminate all microfilariae. Transepidermal DEC resulted in rapid degeneration of microfilariae, and daily single applications of the drug greatly reduced or apparently eliminated microfilariae from the skin. Following weekly topical applications of a DEC emulsion, effective suppression of O. volvulus microfilariae in patients living in a hyperendemic area was maintained for many months; and the dermal pathology resolved.

UI MeSH Term Description Entries
D007988 Liberia A republic in western Africa, south of GUINEA and east of COTE D'IVOIRE. Its capital is Monrovia. Republic of Liberia
D008297 Male Males
D008842 Microfilariae The prelarval stage of Filarioidea found in the blood and tissues of mammals, birds and intermediate hosts (vector). Microfilaria
D009854 Onchocerca A genus of parasitic nematodes whose organisms live and breed in skin and subcutaneous tissues. Onchocercal microfilariae may also be found in the urine, blood, or sputum. Onchocercas
D009855 Onchocerciasis Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions. Onchocerciases
D004049 Diethylcarbamazine An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa. Carbamazine,Diethylcarbamazine Citrate,Diethylcarbamazine Citrate (1:1),Diethylcarbamazine Citrate (1:2),Diethylcarbamazine L-Tartrate (1:1),Diethylcarbamazine Maleate,Diethylcarbamazine Monohydrochloride,Diethylcarbamazine Phosphate (1:1),Hetrazan,Loxuran,Notezine,Citrate, Diethylcarbamazine,Maleate, Diethylcarbamazine,Monohydrochloride, Diethylcarbamazine
D004655 Emulsions Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES. Emulsion
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations

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