-transparent.png){kind=logo}
Resistance to 5-fluorocytosine was studied in 137 independent Candida albicans clinical isolates. Seventy-eight isolates (57%) were susceptible; 51 isolates (37%) were partially resistant; 8 isolates (6%) were highly resistant. All partially resistant isolates gave rise to variants which were highly resistant. Some susceptible isolates gave rise to variants which were highly resistant; two such isolates were shown to be heterozygous for resistance, and these isolates define a new type of heterozygote. A partially resistant isolate gave rise to resistant variants which were auxotrophic for lysine; this result was interpreted as preliminary evidence that the allele which determined resistance was linked to an allele which determined auxotrophy for lysine. It is suggested that heterozygotes constitute a source of preexisting mutant alleles which determine resistance, and that 5-fluorocytosine treatment of infections due to heterozygotes may result in significant selection for resistant variants. A simple screening procedure is described by which partially resistant strains may be recognized.
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
January 1990,
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology,
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
January 2000,
Revista cubana de medicina tropical,
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
May 1986,
Antimicrobial agents and chemotherapy,
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
June 1981,
Antimicrobial agents and chemotherapy,
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
November 1976,
Modern medicine of Asia,
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
August 1972,
British medical journal,
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
November 1974,
Sabouraudia,
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
May 1980,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
October 1984,
Antimicrobial agents and chemotherapy,
K S Defever, and
W L Whelan, and
A L Rogers, and
E S Beneke, and
J M Veselenak, and
D R Soll
September 1989,
The Medical journal of Malaysia,
