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We tested retinyl palmitate for in vivo effects in man and in vitro effects on the IM-9 lymphocyte insulin receptor. Intravenous glucose tolerance tests (IVGTT) with 25 g glucose were performed on 10 healthy subjects before and after two intramuscular injections of retinyl palmitate (25,000 IU) 18 hours apart. In 9 of 10 subjects, glucose disposition was impaired after treatment with retinyl palmitate. In vitro, retinyl palmitate 10(-4) - 10(-6) M did not affect the binding or displacement of insulin 125I from lymphocyte receptors. We conclude that retinyl palmitate decreases glucose tolerance without demonstrable effects on insulin release or insulin binding to receptors.
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
June 2004,
Clinical science (London, England : 1979),
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
October 1971,
Deutsche medizinische Wochenschrift (1946),
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
September 1971,
Deutsche medizinische Wochenschrift (1946),
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
June 1979,
Nihon rinsho. Japanese journal of clinical medicine,
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
January 1957,
Nordisk medicin,
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
March 1938,
Archives of disease in childhood,
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
December 1959,
Acta endocrinologica,
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
November 1985,
The Journal of clinical endocrinology and metabolism,
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
January 1969,
Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie,
B S Chertow, and
W I Sivitz, and
N G Baranetsky, and
T B Styer, and
B J Sorensen, and
C H Schikman, and
R M Norris, and
B A Ozuk
August 1969,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
