Biomaterial Database

Comparative in vitro activities of temocillin and cefazolin against Klebsiella pneumoniae. 1982

H Lagast, and J Klastersky

Temocillin (BRL 17421) a new penicillin, was compared with cefazolin against 20 strains of Klebsiella. The in vitro minimal bactericidal concentration of cefazolin was twice as active as that of temocillin. Serum bactericidal levels obtained in volunteers treated with temocillin were consistently higher than those levels reached after the administration of cefazolin at the 6-h sampling.

UI	MeSH Term	Description	Entries
D007710	Klebsiella Infections	Infections with bacteria of the genus KLEBSIELLA.	Infections, Klebsiella,Infection, Klebsiella,Klebsiella Infection
D007711	Klebsiella pneumoniae	Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.	Bacillus pneumoniae,Bacterium pneumoniae crouposae,Hyalococcus pneumoniae,Klebsiella pneumoniae aerogenes,Klebsiella rhinoscleromatis
D008297	Male		Males
D010403	Penicillin Resistance	Nonsusceptibility of an organism to the action of penicillins.	Penicillin Resistances,Resistance, Penicillin,Resistances, Penicillin
D010406	Penicillins	A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)	Antibiotics, Penicillin,Penicillin,Penicillin Antibiotics
D002437	Cefazolin	A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.	Cephazolin,Ancef,Cefamedin,Cefamezine,Cefazolin Sodium,Cephamezine,Cephazolin Sodium,Gramaxin,Kefzol,Sodium Cephazolin,Totacef,Cephazolin, Sodium,Sodium, Cefazolin,Sodium, Cephazolin
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

H Lagast, and J Klastersky

Therapeutic activities of cefazolin, cefotaxime, and ceftazidime against experimentally induced Klebsiella pneumoniae pneumonia in rats.

December 1982, Antimicrobial agents and chemotherapy,

H Lagast, and J Klastersky

Activity of temocillin against KPC-producing Klebsiella pneumoniae and Escherichia coli.

June 2009, Antimicrobial agents and chemotherapy,

H Lagast, and J Klastersky

Comparative in vitro activity of piperacillin-tazobactam and temocillin against third-generation cephalosporin-resistant, carbapenem-susceptible Escherichia coli and Klebsiella pneumoniae.

January 2021, GMS infectious diseases,

H Lagast, and J Klastersky

Comparative activities of ciprofloxacin and ceftazidime against Klebsiella pneumoniae in vitro and in experimental pneumonia in leukopenic rats.

November 1987, Antimicrobial agents and chemotherapy,

H Lagast, and J Klastersky

Relevance of serum protein binding of cefoxitin and cefazolin to their activities against Klebsiella pneumoniae pneumonia in rats.

November 1985, Antimicrobial agents and chemotherapy,

H Lagast, and J Klastersky

Activity of temocillin and comparators against urinary Escherichia coli and Klebsiella pneumoniae from Iran.

September 2020, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,

H Lagast, and J Klastersky

Activity of temocillin against CTX-M-producing Escherichia coli and Klebsiella pneumoniae from Germany.

January 2018, International journal of antimicrobial agents,

H Lagast, and J Klastersky

Bactericidal activity of cefazolin, cefoxitin, and cefmetazole against Escherichia coli and Klebsiella pneumoniae.

January 1982, Chemotherapy,

H Lagast, and J Klastersky

In vitro and in vivo morphological response of Klebsiella pneumoniae to cefotiam and cefazolin.

May 1981, Antimicrobial agents and chemotherapy,

H Lagast, and J Klastersky

Comparative in-vitro activities of amoxycillin and penicillin against Streptococcus pneumoniae isolates.

September 1998, The Journal of antimicrobial chemotherapy,