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The biologic effect of human insulin (recombinant DNA) and purified pork insulin (PPI) was compared during insulin-induced hypoglycemia at two intravenous dosages 0.075 and 0.1 U/kg body wt in healthy volunteers. Serum insulin concentrations and plasma glucose curves were identical. PPI induced a significantly (P less than 0.05) higher output of epinephrine, growth hormone, and cortisol at both doses. Less inhibition (P less than 0.05) of endogenous insulin secretion was observed for human insulin at 0.1 kg body wt. An elevated incidence of sweating during hypoglycemia was related to epinephrine secretion. The results indicate that homologous insulin produces in vivo effects which are different from those produced by heterologous insulin.
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
May 1988,
Diabetes research (Edinburgh, Scotland),
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
January 1982,
Diabetes care,
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
November 1983,
Drug intelligence & clinical pharmacy,
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
January 1982,
Diabetes care,
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
January 1982,
Diabetes care,
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
August 1991,
Diabetes research and clinical practice,
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
December 1984,
Klinische Wochenschrift,
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
May 1985,
Diabetes research (Edinburgh, Scotland),
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
January 1998,
Allergy,
K J Schlüter, and
K G Petersen, and
J Sontheimer, and
F Enzmann, and
L Kerp
March 1984,
JAMA,
