-transparent.png){kind=logo}
The variable regions of mouse kappa (kappa) chains are coded for by multiple variable (V) gene segments and multiple joining (J) gene segments. The V kappa gene segments code for residues 1 to 95; the J kappa gene segments code for residues 96 to 108 (refs 1-3). This gene organisation is similar to that encoding the V lambda regions. Diversity in V kappa regions arises from several sources: (1) there are multiple germ-line V kappa gene segments and J kappa gene segments; (2) combinatorial joining of V kappa gene segments with different germline J kappa gene segments; and possibly, (3) somatic point mutation, as postulated for V lambda gene segments. Also, from a comparison of the number of germ-line J kappa gene segments and amino acid sequences, it has been suggested that J kappa region sequences may be determined by the way V kappa and J kappa gene segments are joined. This report supports this model by directly associating various J kappa sequences with given J kappa gene segments.
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
January 1995,
Journal of immunology (Baltimore, Md. : 1950),
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
July 1980,
Proceedings of the National Academy of Sciences of the United States of America,
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
January 1984,
Nature,
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
October 1980,
Proceedings of the National Academy of Sciences of the United States of America,
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
March 2010,
Mobile DNA,
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
December 1994,
Seminars in immunology,
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
August 1991,
Journal of immunology (Baltimore, Md. : 1950),
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
June 1984,
Cell,
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
February 1987,
Proceedings of the National Academy of Sciences of the United States of America,
M Weigert, and
R Perry, and
D Kelley, and
T Hunkapiller, and
J Schilling, and
L Hood
March 1981,
Nucleic acids research,
