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The rate of glucose turnover (RT) has been studied in 33 subhuman primate newborn (Macaca mulatta). There appears to be a linear relationship between RT and plasma glucose (G) such that RT = 1.053 G + 0.242. Liver enzymes show a change in specificity such that hexokinase is predominant in the preterm animals and glucokinase has little activity, while in the term animal these enzymes of of equal activity. In the 1-year-old animal glucokinase predominates. Hexokinase activity in the brain remains constant throughout development. These results imply that low blood glucose in the neonate is not associated with increased glucose utilization.
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