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During a 3-yr period, a patient with hemophilia A experienced 5 episodes of acute hepatitis within 7-16 days following 5 separate infusions of factor VIII (FVIII) concentrates. Although the exact mechanism of the recurrent hepatitis remains unclear, these episodes most likely represented repeated allergic reactions to an antigenic protein derived from the FVIII concentrates. Although no evidence was found for a specific humoral immune response to FVIII in the circulation of the patient, an isolated cellular immune response was suggested by the finding of in vitro lymphocyte stimulation in response to the FVIII concentrate. This unusual type of posttransfusion hepatitis must be added to the list of adverse responses to FVIII concentrates.
T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
September 1981,
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T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
April 1988,
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T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
February 1995,
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T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
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T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
January 1986,
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T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
January 1986,
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T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
September 2013,
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T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
July 1994,
Lancet (London, England),
T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
April 1995,
Thrombosis and haemostasis,
T J Myers, and
C L Tembrevilla-Zubiri, and
A U Klatsky, and
F R Rickles
July 2010,
Seminars in thrombosis and hemostasis,
