Biomaterial Database

[Concentration of chloramphenicol in blood, organs, and eggs of poultry after the administration of Chronicin solution ad usum vet. (SPOFA)]. 1980

M Dvorák, and B Sevcík, and L Liebichová

The preparation Chronicin solutio ad usum vet. (SPOFA) (a 15% solution of CHF-base in propylene glycol) is to be orally administered to poultry in drinking water. The recommended doses (5 ml per 1 of water in chickens and turkey-poults and 3 ml per 1 of water in ducklings) produce, in the blood serum, CHF concentrations which act bacteriostatically on sensitive microbial strains [chickens--mean 2.60 micrograms per ml (0.71--6.25), ducks--mean 2.11 micrograms per ml (0.87--4.72)]. After dilution, the preparation is stable in the drinkers at least 24 hours and does not reduce the intake of drinking water in short-term administration. CHF residues remained in the organs of hens six days after the five-day therapy and in the eggs of hens nine days after the therapy. It is recommended, therefore, to respect a nine-day protective period in tissues and a 12-day protective period in eggs (between the end of therapy and processing for consumption).

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D002701	Chloramphenicol	An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)	Cloranfenicol,Kloramfenikol,Levomycetin,Amphenicol,Amphenicols,Chlornitromycin,Chlorocid,Chloromycetin,Detreomycin,Ophthochlor,Syntomycin
D004372	Ducks	A water bird in the order Anseriformes (subfamily Anatinae (true ducks)) with a broad blunt bill, short legs, webbed feet, and a waddling gait.	Duck
D004531	Eggs	Animal reproductive bodies, or the contents thereof, used as food. The concept is differentiated from OVUM, the anatomic or physiologic entity.
D005260	Female		Females
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations