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Increasing reports suggest that clomiphene citrate (clomid) is useful in the treatment of idiopathic hypofertile males. Recent studies have advocated low-dose, cyclic therapy (25 mg daily for 25 days, 5 days' rest) and, although significant clinical responses have been reported, the hormone response has been erratic. This study of 53 patients, given high-dose, alternate-day therapy (100 mg three times/week), shows an over-all positive response rate of 66% and a pregnancy rate of 26%. Significant gonadotropin and testosterone surges were seen in the responders, but a selective lack of a follicle-stimulating hormone surge was noted in a small group of nonresponders. Clomiphene given in this dosage seems to be safe for periods of up to 15 months and appears to be a rational and useful agent for the treatment of this patient group.
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
April 1977,
Urology,
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
July 1981,
The Western journal of medicine,
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
May 1979,
Archives of andrology,
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
May 1988,
Hinyokika kiyo. Acta urologica Japonica,
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
January 1985,
Journal of neurology,
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
November 1989,
American journal of diseases of children (1960),
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
March 1975,
The New England journal of medicine,
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
January 1977,
The American journal of medicine,
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
February 1984,
Ginekologia polska,
L S Ross, and
G L Kandel, and
L M Prinz, and
F Auletta
January 1978,
Acta medica Academiae Scientiarum Hungaricae,
