Biomaterial Database

A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. 1980

J P Brown

Two classes of common phenolic plant pigments, the anthraquinones and the flavonols, contain many members mutagenic in the Salmonella/mammalian microsome assay. Several reports on the mutagenicity or other genetic or "carcinogenic" effects of these compounds have appeared in the literature or have been presented at various scientific meetings. The object of this review paper is to assess the present state of knowledge with respect to the genetic toxicity of these agents and their dietary intake and metabolic fate in man. Such information is necessary for formulating an assessment of genetic or carcinogenic risk to man posed by these agents.

UI	MeSH Term	Description	Entries
D009153	Mutagens	Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.	Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D010944	Plants	Multicellular, eukaryotic life forms of kingdom Plantae. Plants acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations. It is a non-taxonomical term most often referring to LAND PLANTS. In broad sense it includes RHODOPHYTA and GLAUCOPHYTA along with VIRIDIPLANTAE.	Plant
D002273	Carcinogens	Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.	Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D004247	DNA	A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).	DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005419	Flavonoids	A group of phenyl benzopyrans named for having structures like FLAVONES.	2-Phenyl-Benzopyran,2-Phenyl-Chromene,Bioflavonoid,Bioflavonoids,Flavonoid,2-Phenyl-Benzopyrans,2-Phenyl-Chromenes,2 Phenyl Benzopyran,2 Phenyl Benzopyrans,2 Phenyl Chromene,2 Phenyl Chromenes
D005520	Food Preservatives	Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods.	Preservatives, Food
D005821	Genetic Techniques	Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.	Genetic Technic,Genetic Technics,Genetic Technique,Technic, Genetic,Technics, Genetic,Technique, Genetic,Techniques, Genetic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000880	Anthraquinones	Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.	Anthracenedione,Anthracenediones,Anthranoid,Anthraquinone,Anthraquinone Compound,Anthraquinone Derivative,Dianthraquinones,Dianthrones,Anthranoids,Anthraquinone Compounds,Anthraquinone Derivatives,Compound, Anthraquinone,Derivative, Anthraquinone

Related Publications

J P Brown

Solid-phase adsorption methodologies of naturally occurring anthraquinones: A review.

March 2023, Phytochemical analysis : PCA,

J P Brown

Naturally occurring phenalenones and related compounds.

January 1981, Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles,

J P Brown

Structural basis for antiviral activity of flavonoids-naturally occurring compounds.

November 1988, Acta virologica,

J P Brown

Naturally Occurring Organohalogen Compounds-A Comprehensive Review.

January 2023, Progress in the chemistry of organic natural products,

J P Brown

Naturally occurring isocyano/isothiocyanato and related compounds.

January 2000, Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles,

J P Brown

Naturally occurring 2,5-dioxopiperazines and related compounds.

January 1975, Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles,

J P Brown

Naturally Occurring Flavonoids and Isoflavonoids and Their Microbial Transformation: A Review.

November 2020, Molecules (Basel, Switzerland),

J P Brown

Syntheses of naturally occurring terphenyls and related compounds.

December 2006, Bioscience, biotechnology, and biochemistry,

J P Brown

High-pressure liquid chromatography of naturally occurring anthraquinones.

July 1975, Journal of chromatography,

J P Brown

Preparative thin-layer chromatography of naturally occurring anthraquinones.

June 1967, Pharmaceutisch weekblad,