Biomaterial Database

Excretion and disposition of [14C]carbaryl in pregnant, non-pregnant and foetal tissues of the rat after acute administration. 1980

A Strother, and L Wheeler

1. Non-pregnant or pregnant Sprague-Dawley rats on the 18th and 19th days of gestation were injected i.p. with a tracter dose (2.8 microCi/kg) of either [ring-14C]carbaryl or [carbonyl-14C]carbaryl. Distribution of total 14C was examined in foetal, maternal and non-pregnant rat tissues. Pregnancy alters the disposition and excretion of carbaryl. 2. Carbaryl crossed the placenta and was rapidly distributed in all foetal tissues. Highest concentrations were seen in foetal kidney. At 8 h after injection, foetal brain, heart and lung all contained more 14C, on a weight basis, than their maternal organ counterparts. Elimination from the whole foetus was biphasic, and after 8 h approx. 3% of the dose was still present in the whole foetus. 3. Significantly more 14CO2 was exhaled by the pregnant rat during 8 h than by non-pregnant. Urinary excretion of 14C after dosage with [ring-14C]carbaryl was significantly less in pregnant than in non-pregnant rats. 4. Kinetically, the tissue distribution of 14C from carbaryl or metabolites was biphasic in pregnant and non-pregnant animals. [14C]carbaryl concn. declined rapidly for 1 to 2 h. After 2 h the 14C levels from animals dosed with [ring-14C]carbaryl declined more slowly. 5. The pattern of 14C distribution was more complicated after injection of [carbonyl-14C]carbaryl. The 14C activity increased in the animal tissues after 2 h, in contrast to animals dosed with [ring-14C]carbaryl. Non-pregnant animals treated with [carbonyl-14C]carbaryl did not show a similar pattern of distribution. Carbamylated tissue proteins may, after time, release some bound carbonyl-14C label, causing the increase in 14C activity seen between 2 and 8 h. However, this does not necessarily imply uptake of the intact carbamate.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008431	Maternal-Fetal Exchange	Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.	Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D010920	Placenta	A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).	Placentoma, Normal,Placentome,Placentas,Placentomes
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D005243	Feces	Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D005260	Female		Females
D005333	Fetus	The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.	Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal
D006868	Hydrolysis	The process of cleaving a chemical compound by the addition of a molecule of water.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.