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When administered orally, both acetylsalicylic acid and acetylsalicylic acid lysinate produced an increased bleeding time, reduced platelet adhesiveness and inhibition of the second phase of ADP-induced platelet aggregation in the majority of subjects. The effects on bleeding time and adhesiveness were similar for both drugs. Platelet aggregation studies demonstrated slight differences between smokers and non-smokers, in both control samples and in response to the two drugs. It is concluded that aspirin lysinate should provide a good candidate for clinical investigation, to assess its value in the treatment of thrombotic disease.
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