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Smooth-muscle antibodies (SMA) were detected in 16 of 18 (89%) children with neuroblastoma and in 43 of 172 (25%) pediatric hospital patients without malignancies. The SMA were mainly of the IgG class. The most common immunofluorescence pattern was SMA-V (vessel) and titers did not exceed 1:160. Absorption and immunodiffusion tests with action (from rabbit skeletal muscle) showed that the SMA associated with neuroblastoma are mainly directed against actin, although different antigen specificities (myosin, meromyosin) are probably involved in some cases. In both chronic active hepatitis and neuroblastoma, SMA would represent a specific response to intracellular contractile proteins (mainly actin) induced by tissue damage. A feedback role in controlling cellular proliferation has been postulated for experimentally raised SMA. This would be relevant in cases of malignancy.
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
December 1975,
Lancet (London, England),
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
February 1977,
Clinical and experimental immunology,
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
June 1980,
Acta pathologica et microbiologica Scandinavica. Section C, Immunology,
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
November 1988,
Journal of clinical & laboratory immunology,
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
December 2000,
Diagnostic molecular pathology : the American journal of surgical pathology, part B,
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
January 1983,
American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction,
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
May 1976,
Clinical and experimental immunology,
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
January 1962,
Cancer,
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
June 1965,
Cancer,
D Zauli, and
F B Bianchi, and
T Gardelli, and
U Volta, and
M Lenzi, and
A F Mancini, and
E Pisi
October 1982,
Journal of clinical & laboratory immunology,
