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Plasma levels of 14 amino acids were determined in 44 probands with 3/sec spike-wave epilepsy, 27 of their first-degree relatives, and 22 controls. Six ratios of metabolically related amino acids were also calculated. Statistically significant differences were found for 7/20 variables when the experimental and control probands were compared, and for 6/20 variables when the relatives were compared with controls. Tau, Asp, and Tau/Glu were decreased and Glu was was increased in both the experimental probands and their first degree relatives. When discriminant analysis was used, age- and sex-matched epileptic probands could be distinguished from the age- and sex-matched control probands with 100% accuracy employing only 3 amino acids (Asp, Glu, Val) and one ratio (Thr/Ser).
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
April 1972,
Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete,
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
July 1999,
Clinical EEG (electroencephalography),
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
January 1968,
Electroencephalography and clinical neurophysiology,
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
July 1964,
Electroencephalography and clinical neurophysiology,
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
May 1980,
Electroencephalography and clinical neurophysiology,
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
January 1999,
Epilepsia,
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
November 1982,
Revue d'electroencephalographie et de neurophysiologie clinique,
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
January 1983,
Neurochemistry international,
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
January 1991,
Epilepsy research. Supplement,
N M van Gelder, and
N A Janjua, and
K Metrakos, and
B MacGibbon, and
J D Metrakos
January 1962,
Rivista di neurologia,
