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Six adult rabbits were maintained on an 18 h fast, 6 h feeding schedule. At the end of the fast either 0.5-40 Ivy dog units (IDU)/kg cholecystokinin (CCK) or 0.9% NaCl were injected intravenously. Feed intake was then measured for 15 min. Significant depression of intake was found at 1 IDU/kg, a 50% depression of intake after 5.5 IDU/kg, and no intake after 40 IDU/kg. Caerulein in similar experiments gave significant depression of intake at 0.125 microgram/kg, a 50% depression after 0.28 microgram/kg, and no intake after 5.0 microgram/kg. In three of these rabbits subdiaphragmatic vagotomy did not abolish the satiety effects of CCK and caerulein. The synthetic octapeptide of CCK was less potent in causing satiety. After CCK or caerulein the rabbits showed typical postprandial behavior. Taste aversion tests failed to demonstrate a strong aversion to flavors associated with the compounds used. These results indicate that exogenous CCK can act as a satiety agent at levels of the same order as the physiological range.
T R Houpt, and
S M Anika, and
N C Wolff
June 1994,
Gastroenterology,
T R Houpt, and
S M Anika, and
N C Wolff
August 1982,
Neuropharmacology,
T R Houpt, and
S M Anika, and
N C Wolff
November 1982,
European journal of pharmacology,
T R Houpt, and
S M Anika, and
N C Wolff
December 1994,
Gastroenterology,
T R Houpt, and
S M Anika, and
N C Wolff
January 1994,
The International journal of eating disorders,
T R Houpt, and
S M Anika, and
N C Wolff
March 1985,
The American journal of physiology,
T R Houpt, and
S M Anika, and
N C Wolff
October 1970,
The American journal of physiology,
T R Houpt, and
S M Anika, and
N C Wolff
January 1985,
Annals of the New York Academy of Sciences,
T R Houpt, and
S M Anika, and
N C Wolff
January 1977,
Digestion,
