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The amount of the initiating complement component (Clq) in the classical pathway and the first essential component (C3) in the alternative complement pathway were measured with a single radial immunodiffusion (SRID). A high ionic strength was used corresponding to that of 0 . 25 M NaCl and 0 . 01 M EDTA to avoid nonspecific binding of Clq with immune aggregates. Measurements were made on sera and/or synovial fluids from 165 patients with various bone and joint diseases. Values of Clq and C3 in synovial fluids were also expressed as ratios to that of albumin in the same specimens to avoid the influence of differences in volume of synovial fluid in various diseases, and this appeared to provide a reliable index reflecting pathological conditions. Both serum Clq and C3 levels were raised highly in rheumatoid arthritis, gout, and osteomyelitis, but the extent of the elevation of C3 was less conspicuous. Values of Clq and C3 in synovial fluids also markedly increased in rheumatoid arthritis.
T Ochi, and
K Yonemasu, and
K Ono
January 1977,
The Journal of laboratory and clinical medicine,
T Ochi, and
K Yonemasu, and
K Ono
January 1978,
Allergie und Immunologie,
T Ochi, and
K Yonemasu, and
K Ono
April 1975,
Annals of the rheumatic diseases,
T Ochi, and
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K Ono
November 1979,
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T Ochi, and
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March 1990,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
T Ochi, and
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Polski tygodnik lekarski (Warsaw, Poland : 1960),
T Ochi, and
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January 1996,
Clinical and experimental rheumatology,
T Ochi, and
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January 1991,
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T Ochi, and
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K Ono
September 1980,
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T Ochi, and
K Yonemasu, and
K Ono
November 1973,
Clinical immunology and immunopathology,
