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Maternal and fetal hemodynamic effects and placental transfer of midazolam (RO 21-3981, Hoffman-LaRoche) and diazepam were studied in chronically instrumented pregnant ewes. Diazepam administration resulted in greater increases of maternal and fetal heart rates and maternal blood pressure, and greater alteration of total uterine blood flow than did administration of comparable doses of midazolam. Neither drug altered fetal mean arterial pressure or maternal and fetal respiratory gases. Although the absolute blood concentrations were higher, the fetal:maternal drug concentration ratios were consistently less for midazolam than for diazepam, suggesting less placental permeability of midazolam.
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
July 2005,
Veterinary journal (London, England : 1997),
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
June 1981,
Journal of developmental physiology,
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
September 1996,
European journal of obstetrics, gynecology, and reproductive biology,
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
January 1978,
Advances in prostaglandin and thromboxane research,
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
April 1983,
Journal of developmental physiology,
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
January 1985,
Anesthesiology,
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
August 1986,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
August 1997,
Anesthesia and analgesia,
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
July 1975,
Canadian Anaesthetists' Society journal,
K A Conklin, and
C W Graham, and
S Murad, and
F M Randall, and
R L Katz, and
T Cabalum, and
S M Lieb, and
C R Brinkman
March 1993,
Anesthesiology,
