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Triacylglycerides (TAG), total cholesterol (TC) and serum lipoproteins (SLP) were studied during the course of 12 cases of human malaria and one case of simian inui malaria. The erythrocytic schizogony induced quickly an increase of TAG, a decrease of TC and modifications of SLP such an increase of VLDL parallel with a decrease or a disappearance of HDL. These modifications, always clear-cut, were not correlated with the intensity of parasitaemia or the species of Plasmodium. They were transient but longer than those described in connection with experimental rodent malaria. The changes of HDL could be associated with defective triglyceride removal of the plasma compartment due to an inhibition of the lipoprotein lipase induced by the parasite.
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