Biomaterial Database

Transduction of amikacin, gentamicin and tobramycin resistance in Pseudomonas aeruginosa. 1980

H Knothe, and V Krcméry, and S Mitsuhashi

In a series of Pseudomonas aeruginosa strains resistant to gentamicin, tobramycin, amikacin and/or netilmicin (Knothe and Krcméry, 1979), wild-type phage lysates could be prepared and two of them were studied more in detail. Both lysates were shown to mediate transfer of gentamicin, amikacin and carbenicillin resistance by direct selection. In some instances also fertility function (tra) could be demonstrated in transductants by further cycles of transfer. It could be speculated that, once such wild-type phages from resistant or toxinogenic strains are liberated into the hospital environment, they could mediate these and other properties to P. aeruginosa strains in that environment.

UI	MeSH Term	Description	Entries
D007612	Kanamycin	Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.	Kanamycin A,Kanamycin Sulfate,Kantrex
D008242	Lysogeny	The phenomenon by which a temperate phage incorporates itself into the DNA of a bacterial host, establishing a kind of symbiotic relation between PROPHAGE and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium. Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium.	Integration, Prophage,Prophage Integration,Integrations, Prophage,Prophage Integrations
D011550	Pseudomonas aeruginosa	A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.	Bacillus aeruginosus,Bacillus pyocyaneus,Bacterium aeruginosum,Bacterium pyocyaneum,Micrococcus pyocyaneus,Pseudomonas polycolor,Pseudomonas pyocyanea
D004352	Drug Resistance, Microbial	The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).	Antibiotic Resistance,Antibiotic Resistance, Microbial,Antimicrobial Resistance, Drug,Antimicrobial Drug Resistance,Antimicrobial Drug Resistances,Antimicrobial Resistances, Drug,Drug Antimicrobial Resistance,Drug Antimicrobial Resistances,Drug Resistances, Microbial,Resistance, Antibiotic,Resistance, Drug Antimicrobial,Resistances, Drug Antimicrobial
D005144	F Factor	A plasmid whose presence in the cell, either extrachromosomal or integrated into the BACTERIAL CHROMOSOME, determines the "sex" of the bacterium, host chromosome mobilization, transfer via conjugation (CONJUGATION, GENETIC) of genetic material, and the formation of SEX PILI.	Resistance Transfer Factor,Sex Factor F,Sex Factor, Bacterial,Bacterial Sex Factor,Bacterial Sex Factors,F Plasmid,F Plasmids,Factor, Bacterial Sex,Factors, Bacterial Sex,Fertility Factor, Bacterial,Sex Factors, Bacterial,Bacterial Fertility Factor,Bacterial Fertility Factors,F Factors,Factor F, Sex,Factor Fs, Sex,Factor, Bacterial Fertility,Factor, F,Factor, Resistance Transfer,Factors, Bacterial Fertility,Factors, F,Factors, Resistance Transfer,Fertility Factors, Bacterial,Fs, Sex Factor,Plasmid, F,Plasmids, F,Resistance Transfer Factors,Sex Factor Fs,Transfer Factor, Resistance,Transfer Factors, Resistance
D005839	Gentamicins	A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	Gentamicin Sulfate (USP),Gentamycin,G-Myticin,Garamycin,Gentacycol,Gentamicin,Gentamicin Sulfate,Gentamycins,Gentavet,Genticin,G Myticin,GMyticin,Sulfate, Gentamicin
D000583	Amikacin	A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.	A.M.K,Amikacin Sulfate,Amikacina Medical,Amikacina Normon,Amikafur,Amikalem,Amikason's,Amikayect,Amikin,Amiklin,Amukin,BB-K 8,BB-K8,Biclin,Biklin,Gamikal,Kanbine,Oprad,Yectamid,BB K 8,BB K8,BBK 8,BBK8,Medical, Amikacina,Normon, Amikacina,Sulfate, Amikacin
D000900	Anti-Bacterial Agents	Substances that inhibit the growth or reproduction of BACTERIA.	Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D014031	Tobramycin	An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.	Nebramycin Factor 6,Brulamycin,Nebcin,Nebicin,Obracin,Tobracin,Tobramycin Sulfate,Sulfate, Tobramycin
D014161	Transduction, Genetic	The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.	Genetic Transduction,Genetic Transductions,Transductions, Genetic

Related Publications

H Knothe, and V Krcméry, and S Mitsuhashi

Comparative activity of netilmicin, gentamicin, amikacin, and tobramycin against Pseudomonas aeruginosa and Enterobacteriaceae.

October 1976, Antimicrobial agents and chemotherapy,

H Knothe, and V Krcméry, and S Mitsuhashi

Comparative activity of tobramycin, amikacin, and gentamicin alone and with carbenicillin against Pseudomonas aeruginosa.

October 1974, Antimicrobial agents and chemotherapy,

H Knothe, and V Krcméry, and S Mitsuhashi

Amikacin, gentamicin and tobramycin resistant Pseudomonas aeruginosa in a leukaemic ward. Epidemiology and genetic studies.

September 1982, The Journal of hospital infection,

H Knothe, and V Krcméry, and S Mitsuhashi

Transduction, by phases F116 and G101, of gentamicin-tobramycin resistance, and of "autoplaque formation" property in Pseudomonas aeruginosa.

November 1977, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,

H Knothe, and V Krcméry, and S Mitsuhashi

Activity of amikacin, gentamicin and tobramycin combined with carbenicillin or ticarcillin against Pseudomonas aeruginosa in vitro.

January 1985, Archives roumaines de pathologie experimentales et de microbiologie,

H Knothe, and V Krcméry, and S Mitsuhashi

In vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa.

August 1983, Antimicrobial agents and chemotherapy,

H Knothe, and V Krcméry, and S Mitsuhashi

Evaluation of the automicrobic system for susceptibility testing of Pseudomonas aeruginosa to gentamicin, tobramycin, and amikacin.

April 1984, Journal of clinical microbiology,

H Knothe, and V Krcméry, and S Mitsuhashi

Global and effective synergism of amikacin, gentamicin or tobramycin when combined with carbenicillin against Pseudomonas aeruginosa.

January 1979, The Journal of international medical research,