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Laboratory rabbits were exposed for 60 min to aerosols of dry cardroom cotton dust 4 days/wk (Tuesday through Friday) for 15 consecutive weeks. As a parameter of pulmonary pathophysiology, arterial blood gases were monitored with time after challenge. Post-exposure blood gas analyses at 1 hr showed progressive decreases in arterial oxygen tension, with concommitant increases in arterial carbon dioxide tension and the alveolar-arterial oxygen gradient. These responses appeared to result from acute reversible airway obstruction which caused unequal gas distribution and ventilation-perfusion inequalities. When a group of proven responder rabbits was challenged with cardroom cotton dust which was first treated in a manner which paralleled the preparation of medical grade cotton, only minor decreases in arterial oxygen tension were observed. The data suggest that some, as yet undefined, agent(s) which was removed by the treatment was responsible for inciting the observed pathophysiology.
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