-transparent.png){kind=logo}
To clarify the controversy regarding the benefits of long-term oral digoxin in the treatment of heart failure, we evaluated hemodynamics at rest and during exercise in nine patients in sinus rhythm with symptomatic heart failure. Patients were studied during long-term digoxin therapy, after withdrawal of the drug, and six hours after readministration. Upon withdrawal of digoxin, pulmonary capillary-wedge pressure increased from 21 +/- 8 to 29 +/- 10 mm Hg, and cardiac index decreased from 2.4 +/- 0.7 to 2.1 +/- 0.6 liters per minute per square meter of body-surface area, suggesting a deterioration in left ventricular function. In addition, heart rate tended to increase and stroke-work index, stroke-volume index, and radioangiographic ejection fraction decreased. Acute readministration restored the hemodynamic values to those observed during long-term digoxin therapy. The improvement in hemodynamics during long-term digoxin administration was also observed during exercise. This improvement demonstrated the value of long-term oral digoxin therapy in congestive heart failure.
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
April 1981,
The New England journal of medicine,
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
May 2002,
Hypertension (Dallas, Tex. : 1979),
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
January 2012,
PloS one,
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
August 2015,
Molecular medicine reports,
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
May 1995,
The American journal of medicine,
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
September 2018,
The American journal of cardiology,
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
January 2021,
Transplantation proceedings,
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
July 2006,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
April 1987,
La Clinica terapeutica,
S B Arnold, and
R C Byrd, and
W Meister, and
K Melmon, and
M D Cheitlin, and
J D Bristow, and
W W Parmley, and
K Chatterjee
December 2019,
European heart journal supplements : journal of the European Society of Cardiology,
