Biomaterial Database

Investigations on the interaction of thyrotropin-releasing hormone (TRH) and MK-771 with central noradrenergic mechanisms. 1980

V J Lotti, and G G Yarbrough, and B V Clineschmidt

Thyrotropin-releasing hormone (TRH) and a structurally related analogue of TRH, MK-771, administered IP or orally, restored flex or reflex activity in rats with acute spinal transections. The effect of MK-771 in this test was not modified by pretreatment with reserpine plus alpha-methyl-p-tyrosine but was antagonized by the alpha-adrenergic blocking agent, phenoxybenzamine. However, another alpha-adrenergic blocking agent, HEAT, was ineffective in this regard. Additionally, TRH and MK-771 restored the anticonvulsant actions of methazolamide in mice pretreated with reserpine or picolinic acid. These data, along with the findings that MK-771 and TRH enhance depletion of brain norepinephrine induced by alpha-methyl-p-tyrosine, indicate that these agents may affect central noradrenergic mechanisms. Whether the mechanism of their proposed effect upon noradrenergic systems is direct or mediated by an interaction with another neurotransmitter system which influences noradrenergic function cannot be determined on the basis of the present studies.

UI	MeSH Term	Description	Entries
D008704	Methazolamide	A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.	N-Methylacetazolamide,N Methylacetazolamide
D008781	Methyltyrosines	A group of compounds that are methyl derivatives of the amino acid TYROSINE.
D009638	Norepinephrine	Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.	Levarterenol,Levonorepinephrine,Noradrenaline,Arterenol,Levonor,Levophed,Levophed Bitartrate,Noradrenaline Bitartrate,Noradrénaline tartrate renaudin,Norepinephrin d-Tartrate (1:1),Norepinephrine Bitartrate,Norepinephrine Hydrochloride,Norepinephrine Hydrochloride, (+)-Isomer,Norepinephrine Hydrochloride, (+,-)-Isomer,Norepinephrine d-Tartrate (1:1),Norepinephrine l-Tartrate (1:1),Norepinephrine l-Tartrate (1:1), (+,-)-Isomer,Norepinephrine l-Tartrate (1:1), Monohydrate,Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer,Norepinephrine l-Tartrate (1:2),Norepinephrine l-Tartrate, (+)-Isomer,Norepinephrine, (+)-Isomer,Norepinephrine, (+,-)-Isomer
D012018	Reflex	An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
D001923	Brain Chemistry	Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.	Chemistry, Brain,Brain Chemistries,Chemistries, Brain
D002395	Catecholamines	A general class of ortho-dihydroxyphenylalkylamines derived from TYROSINE.	Catecholamine,Sympathin,Sympathins
D002490	Central Nervous System	The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.	Cerebrospinal Axis,Axi, Cerebrospinal,Axis, Cerebrospinal,Central Nervous Systems,Cerebrospinal Axi,Nervous System, Central,Nervous Systems, Central,Systems, Central Nervous
D004151	Dipeptides	Peptides composed of two amino acid units.	Dipeptide
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia