-transparent.png){kind=logo}
A method for the large scale preparation of partially desialylated human chorionic gonadotrophin suitable for human use is reported. To obtain the desired grade of desialylation and to avoid the presence of the enzyme in the modified hormone, neuraminidase coupled to Sepharose 4B was used. The preparation showed to be active in vitro (OAAD and SVW tests) and its half-life was found to be 13 min in the rat and 75 min in human beings. This desialo hCG proved to be effective in inducing ovulation in amenorrhoeic women. Among 39 induced cycles 31 ovulations and 5 pregnancies occurred.
Related Publications
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
January 1983,
Reproduccion,
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
September 1984,
Asia-Oceania journal of obstetrics and gynaecology,
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
March 1996,
Human reproduction (Oxford, England),
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
January 1969,
International journal of fertility,
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
October 1995,
Human reproduction (Oxford, England),
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
March 1983,
Fertility and sterility,
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
February 1979,
Acta endocrinologica,
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
February 1975,
Acta endocrinologica,
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
May 1974,
The Journal of endocrinology,
P G Crosignani, and
P Donini, and
G C Lombroso, and
S Donini, and
A Caccamo, and
L Trojsi
July 2015,
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
